High-throughput methods allow the simultaneous measurement of many cellular variables, such as protein content, gene expression or cell state. They have become an integrated part of current biological research to unravel the complexity of living systems and technology is advancing at a rapid pace. This seminar is aimed at presenting the latest methods in proteomics, genomics and deep sequencing, as well as strategies to turn this data into new discoveries in biology and treatments in medicine.

Dozenten:

PD Dr. Stefan Rensing

Dr. Hauke Busch

Dr. Jörn Dengjel

Dr. Melanie Boerries

Dr. Arnd Brandenburg

Zeit und Ort: Blockseminar am 2. Februar 2012, ZBSA Seminarraum, Habsburger Str. 49

Anmeldung und Themenwunsch per e-mail

Vorbesprechung: Dienstag 20. 10. 2011, 14:00 Uhr, Seminarraum ZBSA

• Thema: Using Mass spectrometry to Identify posttranslational modification of proteins
  • Literatur: Choudhary et al.: Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
  • Betreuer: Jörn Dengjel
  • Voretragender: Maxi Göthe
• Thema: Proteome of Stem Cells
  
  • Literatur: Rigbolt, et al.: System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation
  • Betreuer: Jörn Dengjel
  • Vortragender: Aydan Karslioglu

 

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• Thema: RNA-seq
  • Literatur: Bullard et al.: RNA-seq: Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments
• Betreuer: Arnd Brandenburg
• Vortragender: Jiabin Huang

• Thema: Next generation Sequencing- putting it all together
  
  • Literatur: Trapnell et al.: Transcript assembly and quantification by RNA-seq reveals unannotated transcripts and isoform switching during cell differentiation
  • Betreuer: Arnd Brandenburg
  • Vortragender: Kai Gräber

• Thema: Chip-seq - How does it work?
  • Literatur: Lefrancois et al.: ChIP-Seq: Using High-Throughput DNA Sequencing for Genome-Wide Identification of Transcription Factor Binding Sites
• Betreuer: Stefan Rensing
• Vortragende: Antje Vögele

• Thema: The Arabidopsis epigenome map
• Literatur: Roudier et al.: Integrative epigenomic mapping defines four main chromatin states in Arabidopsis
• Betreuer: Stefan Rensing
• Vortragende: Kerstin Rönsch

• Thema: Systems Biology: Network theory of cell differentiation
  
  • Literatur: Rajapakse et al. Networking the Nucleus
  • Betreuer: Hauke Busch
  • Vortragende: Valentina Perrera

• Thema: Correlation between Transcriptome and Proteome
  • Literatur: Lee et al. A dynamic model of proteome changes reveals new roles for transcript alteration in yeast.
  • Betreuer: Hauke Busch
  • Vortragender: Shaobo Wang

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• Thema: Sytems Biology for Drug discovery
• Literatur: Cohen et al.: A pharmacogenomic method for individualized prediction of drug sensitivity
  Betreuer: Melanie Börries
• Vortragender: Sabine Jaegle

• Thema: Polycystic Kidney Disease
  
  • Literatur: Pandey et al.: Systems biology approach to identify transcriptome reprogramming and candidate
    microRNA targets during the progression of polycystic kidney disease
  • Betreuer: Melanie Börries
  • Vortragender: Yun Hee Kim