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Publications

 

       A. Original research articles:

  1. Brummer, T., Shaw, P.E., Reth, M. and Misawa, Y. (2002): Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. Embo Journal, 21, 5611-5622. 
  2. Flemming, A., Brummer, T., Reth, M. and Jumaa, H. (2003): The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nature Immunology, 4, 38-43.        
  3. Brummer, T., Naegele, H., Reth, M. and Misawa, Y. (2003): Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf. Oncogene, 22, 8823-8834.  
  4. Brummer, T., Stéhelin, D., Reth, M. and Misawa, Y. (2004): A revised and complete map of the chicken c-mil/raf-1 locus. Oncogene, 23, 3128-3131.
  5. Minguet, S., Huber, M., Rosenkranz, L., Schamel, W.W., Reth, M.* and Brummer, T.* (2005): Adenosine and cAMP are potent inhibitors of the NF-kB pathway downstream of immunoreceptors. * corresponding author. European Journal of Immunology, 35, 31-41.
  6. Brummer, T.#, Schramek, D. #, Hayes, V., Bennett, H.L., Caldon, C.E., and Daly, R.J. (2006a): Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. Journal of Biological Chemistry, 281, 626-637. #joint first authors.
  7. Jeffrey, K.L., Brummer, T., Rolph, M.S., Liu, S., Callejas, N.A., Grumont, R.J., Gillieron, C., Mackay, F., Grey, S., Camps, M., Rommel, C., Gerondakis, S. and Mackay, C.R. (2006): Positive regulation of immune cell function and inflammatory responses by PAC-1 phosphatase. Nature Immunology, 7, 274-283
  8. Brummer, T.*, Martin, P., Herzog, S., Misawa, Y., Daly, R.J. and M. Reth (2006b): Functional analysis of the regulatory requirements of B-Rafand the B-RafV600E oncoprotein. Oncogene, 25, 6262 – 6276. *corresponding author
  9. Bennett, H.L., Brummer, T., Jeanes, A., Yap, A.S. and R.J. Daly (2008): Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis. Oncogene 27(19):2693-704.
  10. Brummer, T., Larance, M., Herrera, M., Timpson, P., Emmerich, C., Guilhaus, M., James, D.E. and R.J. Daly (2008): Phosphorylation dependent binding of 14-3-3 proteins terminates signalling by the Gab2 docking protein. EMBO J 27 (17), pp. 2305-2316.B.)

     

    B. Review articles:

  11. Patterson, K.I., Brummer, T., O'Brien, P. and Daly R.J. (2009): Dual Specificity Phosphatases: Critical Regulators with Diverse Cellular Targets. Biochemical Journal, in press.

  12. Reth, M. and Brummer, T. (2004): Feedback regulation of lymphocyte signalling. Nature Reviews Immunology, 4, 269-277.

     

    C. Book chapters and other invited contributions:

  13. Brummer, T. (2008): "B-Raf signalling". Essay for the second edition of the Encyclopedia of Cancer (Springer). Edited by Manfred Schwab. Manuscript in press.

  14. Brummer, T. (2008): "B-Raf somatic alterations". Essay for the second edition of the Encyclopedia of Cancer (Springer). Edited by Manfred Schwab. Manuscript in press.

  15. Bennett, H.L., Brummer, T., Timpson, P., Patterson, K.I. and Daly, R.J. (2008): Signalling by the EGF receptor in human cancers: accentuate the positive, eliminate the negative. Chapter II-3, p. 235-255, in "EGFR Signaling Networks in Cancer Therapy", edited by Bill Gullick and John D Haley. Humana Press Inc. Totowa, NJ, USA. 

  16. Jeffrey, K.L., Mackay, C.R. and Brummer, T. (2006): Transfection of bone marrow-derived mast cells for transcription factor luciferase reporter assays. Nature Protocols, Protocols network online publication DOI:10.1038/nprot.2006.218. http://www.natureprotocols.com/2006/09/12/transfection_of_bone_marrowder_1.php

  17. Brummer, T., Elis, W., Reth, M. and Huber, M. (2004): B-cell signal transduction: tyrosine phosphorylation, kinase activity, and calcium mobilization. Chapter 14 in "B cell protocols", Methods in Molecular Biology, 271, 189-212. Humana Press Inc. Totowa, NJ, USA. Edited by Hua Gu und Klaus Rajewsky.