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Gerd Walz

Abteilung Innere Medizin IV
stellvertretender Direktor

Tel: 0049(0)761- 270 3250
E-Mail: walz@med1.ukl.uni-freiburg.de

 

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CV

 

 

Name:Walz
First Name:Gerd
Birth:   10.01.1957 in Gelsenkirchen, Germany
Nationality:German
Position/Title:   Chief, Renal Division / Professor (C4)
Social Status:      Married, 2 children
   
Education:

 

1963 - 1967   Primary school in Gelsenkirchen and Espelkamp
1967 - 1975  High school, Espelkamp, final exam: Abitur
1975 - 1976  Mathemetics, Technical University, Berlin
1976 - 1983   Medical School, University Berlin and Tübingen
 

Scientific education:

 

1993 - 1987 Resident, University Hospital, Berlin
1987 - 1989 Postdoctoral Fellow, Transplant Immunology, Beth Israel Hospital, Harvard Medical School, Boston, USA
1989 - 1992Postdoctoral Fellow, Department of Molecular Biology, Massachussetts General Hospital, Harvard Medical School, Boston
1992Habilitation (Venia legendi). University Berlin.
1992 - 1994 Resident, Beth Israel Hospital, Harvard Medical School, Boston, USA
1994 - 1995Renal Fellow, Brigham and Women’s Hospital, Instructor in Medicine, Harvard Medical School, Boston, USA
1995 - 1999Attening Physician, Beth Israel Hospital, Assistant Professor of Medicine, Harvard Medical School, Boston, USA
1999 -Professur (C4), Chief, Renal Division, University Hospital Freiburg
2007 -Member, Board of Directors, Center of Systemsbiology, Freiburg

 

Scientific honors (including editorial work)

 

1989  Transplantation Award, ASTP, Chicago
1991    Special Fellowship, Leukemia Society America, USA
1995-Ad-Hoc Reviewer (Cell, Science, Nature Genetics, etc.)
1997  Member, NIH Study Section „Polycystic Kidney Disease“
2002-2004Panel Member, Welcome Trust, London
2006-Academic Consultant, Institute of Nephrology, Changzheng Mecidal University, Shangai, China
2007-Editoral Board, Journal of the American Society of Nephrology
 

         

Publikationen (2007-2002)

 

I. Peer Review (selected from 32 publications)
 
1.    Kotsis, F., Nitschke, R., Boehlke, C., Bashkurov, M., Walz, G., and Kuehn, E. W. (2007). Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1). Pflugers Arch453, 819-829.
2.    Wegierski, T., Hill, K., Schaefer, M., and Walz, G. (2006). The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. Embo J25, 5659-5669.
3.    Shillingford, J. M., Murcia, N. S., Larson, C. H., Low, S. H., Hedgepeth, R., Brown, N., Flask, C. A., Novick, A. C., Goldfarb, D. A., Kramer-Zucker, A., Walz, G., Piontek, K. B., Germino, G. G., and Weimbs, T. (2006). The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A103, 5466-5471.
4.    Schermer, B., Ghenoiu, C., Bartram, M., Muller, R. U., Kotsis, F., Hohne, M., Kuhn, W., Rapka, M., Nitschke, R., Zentgraf, H., Fliegauf, M., Omran, H., Walz, G., and Benzing, T. (2006). The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol175, 547-554.
5.    Sayer, J. A., Otto, E. A., O'Toole, J. F., Nurnberg, G., Kennedy, M. A., Becker, C., Hennies, H. C., Helou, J., Attanasio, M., Fausett, B. V., Utsch, B., Khanna, H., Liu, Y., Drummond, I., Kawakami, I., Kusakabe, T., Tsuda, M., Ma, L., Lee, H., Larson, R. G., Allen, S. J., Wilkinson, C. J., Nigg, E. A., Shou, C., Lillo, C., Williams, D. S., Hoppe, B., Kemper, M. J., Neuhaus, T., Parisi, M. A., Glass, I. A., Petry, M., Kispert, A., Gloy, J., Ganner, A., Walz, G., Zhu, X., Goldman, D., Nurnberg, P., Swaroop, A., Leroux, M. R., and Hildebrandt, F. (2006). The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet38, 674-681.
6.    Huber, T. B., Schermer, B., Muller, R. U., Hohne, M., Bartram, M., Calixto, A., Hagmann, H., Reinhardt, C., Koos, F., Kunzelmann, K., Shirokova, E., Krautwurst, D., Harteneck, C., Simons, M., Pavenstadt, H., Kerjaschki, D., Thiele, C., Walz, G., Chalfie, M., and Benzing, T. (2006). Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A103, 17079-17086.
7.    Horndasch, M., Lienkamp, S., Springer, E., Schmitt, A., Pavenstadt, H., Walz, G., and Gloy, J. (2006). The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals. Oncogene25, 3397-3407.
8.    Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Kronig, C., Schermer, B., Benzing, T., Cabello, O. A., Jenny, A., Mlodzik, M., Polok, B., Driever, W., Obara, T., and Walz, G. (2005). Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet37, 537-543.
9.    Schermer, B., Hopker, K., Omran, H., Ghenoiu, C., Fliegauf, M., Fekete, A., Horvath, J., Kottgen, M., Hackl, M., Zschiedrich, S., Huber, T. B., Kramer-Zucker, A., Zentgraf, H., Blaukat, A., Walz, G., and Benzing, T. (2005). Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. Embo J24, 4415-4424.
10.Kottgen, M., Benzing, T., Simmen, T., Tauber, R., Buchholz, B., Feliciangeli, S., Huber, T. B., Schermer, B., Kramer-Zucker, A., Hopker, K., Simmen, K. C., Tschucke, C. C., Sandford, R., Kim, E., Thomas, G., and Walz, G. (2005). Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. Embo J24, 705-716.
11.Gerke, P., Sellin, L., Kretz, O., Petraschka, D., Zentgraf, H., Benzing, T., and Walz, G. (2005). NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. J Am Soc Nephrol16, 1693-1702.
12.Sellin, L., Huber, T. B., Gerke, P., Quack, I., Pavenstadt, H., and Walz, G. (2003). NEPH1 defines a novel family of podocin interacting proteins. Faseb J17, 115-117.
13.Otto, E. A., Schermer, B., Obara, T., O'Toole, J. F., Hiller, K. S., Mueller, A. M., Ruf, R. G., Hoefele, J., Beekmann, F., Landau, D., Foreman, J. W., Goodship, J. A., Strachan, T., Kispert, A., Wolf, M. T., Gagnadoux, M. F., Nivet, H., Antignac, C., Walz, G., Drummond, I. A., Benzing, T., and Hildebrandt, F. (2003). Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet34, 413-420.
14.Olbrich, H., Fliegauf, M., Hoefele, J., Kispert, A., Otto, E., Volz, A., Wolf, M. T., Sasmaz, G., Trauer, U., Reinhardt, R., Sudbrak, R., Antignac, C., Gretz, N., Walz, G., Schermer, B., Benzing, T., Hildebrandt, F., and Omran, H. (2003). Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nat Genet34, 455-459.
15.Huber, T. B., Schmidts, M., Gerke, P., Schermer, B., Zahn, A., Hartleben, B., Sellin, L., Walz, G., and Benzing, T. (2003). The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1. J Biol Chem278, 13417-13421.
16.Huber, T. B., Hartleben, B., Kim, J., Schmidts, M., Schermer, B., Keil, A., Egger, L., Lecha, R. L., Borner, C., Pavenstadt, H., Shaw, A. S., Walz, G., and Benzing, T. (2003). Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol23, 4917-4928.
17.Gerke, P., Huber, T. B., Sellin, L., Benzing, T., and Walz, G. (2003). Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. J Am Soc Nephrol14, 918-926.
18.Huber, T. B., Simons, M., Hartleben, B., Sernetz, L., Schmidts, M., Gundlach, E., Saleem, M. A., Walz, G., and Benzing, T. (2003). Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet12, 3397-3405.
19.Nickel, C., Benzing, T., Sellin, L., Gerke, P., Karihaloo, A., Liu, Z. X., Cantley, L. G., and Walz, G. (2002). The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. J Clin Invest109, 481-489.
20.Benzing, T., Kottgen, M., Johnson, M., Schermer, B., Zentgraf, H., Walz, G., and Kim, E. (2002). Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha. J Biol Chem277, 32954-32962.
 
II. Reviews (2007-2002) (selected from 10)
 
1.    Benzing, T., Simons, M., and Walz, G. (2007). Wnt signaling in polycystic kidney disease. J Am Soc Nephrol18, 1389-1398.
2.    Simons, M., and Walz, G. (2006). Polycystic kidney disease: cell division without a c(l)ue? Kidney Int70, 854-864.
3.    Benzing, T., and Walz, G. (2006). Cilium-generated signaling: a cellular GPS? Curr Opin Nephrol Hypertens15, 245-249.
4.    Kottgen, M., and Walz, G. (2005). Subcellular localization and trafficking of polycystins. Pflugers Arch451, 286-293.